Study challenges conventional wisdom that sight-based brain sensory network is impaired with blindness

Is visual input essential to how the topographical map of the visual cortex develops in the human brain? In a new research, scientists at the Hebrew University of Jerusalem, and those from in Germany and USA, show that the way in which the brain organizes its visual sense remains intact even in people who are blind from birth.


The scientists also note that at least the pattern of functional connectivity between the visual area and the topographical representation of space (up/down, left/right, etc.) can develop on its own without any actual visual experience. The findings, reported in the journal Brain, dispel the nearly half-century belief that the visual cortex — the area of the brain concerned with the sense of sight — completely fails to develop properly in people who are blind at birth, suggesting it might not be completely correct.

Though the 'blind brain' wiring may change greatly in the blind in its frontal language related parts, it still retains the most fundamental topographical and functional connectivity organizational principles of the visual cortex, known as 'retinotopic mapping' — the processing of two-dimensional visual images through the eye, as per the co-lead researcher Amir Amedi, Associate Professor of Medical Neurobiology at the Hebrew University's Edmond and Lily Safra Center for Brain Sciences and IMRIC, the Institute for Medical Research Israel-Canada.

The researchers found that the same "mapping" divisions-of-labor present in the normally sighted brain are also present in the brains of people born blind as reflected from their resting state connectivity patterns. This fundamental organization of the visual cortex was even found in people whose eyes did not develop normally, suggesting normal eye development may not be necessary for the establishment of large-scale functional connectivity network mapping in the most fundamental visual areas like V1, the primary visual cortex. Contrary to conventional wisdom, the latest findings reported by Prof. Amir Amedi, Dr. Ella Striem-Amit and Smadar Ovadia-Caro suggest that some key features and properties of visual cortex organization do not require visual experience to progress. The study further adds that the brain's visual cortex does not lose all of its properties even when completely deprived of vision.

The authors add that some of the brain’s connectivity maps is hardwired, possibly dependent on genetically-driven processes that do not need any external sensory information for their activation, while other process might indeed need visual input to specialize, The visual brain resting-state connectivity networks separated to up vs. down, right vs. left, front vs. back are also present in the brain of those born blind.

Previous research by neurophysiologists David Hubel and Torsten Wiesel, which earned them a Nobel Prize in 1981, suggested that sight restoration could not be attempted on people blind from birth. Therefore, they surmised, the blinded cortex could not enable the blind-from-birth to have sight.

This latest research, combined with other research conducted in the Amedi Lab for Multisensory Research, suggests that it may be possible to successfully teach blind people to 'see with sounds and touch.' Using tools of sensory substitution, it may be possible to aid people born blind (or late blind) in a variety of new ways in the future, including restoring high-order functional pattern recognition for objects, localization, shape and even numbers and text, as previously reported in the journal Nature Communications.

Useful content:

• Amedi Lab allows any interested person, including people with visual impairment, to download and train themselves on using such technologies for free. Please click here.
• Videos and images are available here. If you plan to use it anywhere, please attribute it to Amedi lab.

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