Understanding eye diseases is tricky enough. Knowing what causes them at the molecular level is even more confounding.
To understand eye diseases better, University of Iowa (UI) researchers have created the most detailed
map to date of a region of the human eye long associated with blinding
diseases, such as age-related macular degeneration. The high-resolution
molecular map catalogs thousands of proteins in the choroid, which
supplies blood and oxygen to the outer retina, itself critical in
vision. By seeing differences in the abundance of proteins in different
areas of the choroid, the researchers can begin to figure out which
proteins may be the critical actors in vision loss and eye disease.